Massaging injection sites after an injection of one of the disease-modifying drugs for multiple sclerosis (MS) can really help reduce irritation in these areas. However, it is extremely important to pay attention to the rules of WHEN is the best time to massage your injection sites, which depends on which medication you are taking.
If You Are Using Betaseron, Avonex , Rebif:
It is recommended that you massage the injection site for the interferons immediately following the injection.
Some recommend massaging the site gently with a dry cotton ball or gauze for two minutes or more. This is supposed to help disperse the medication, as well as reduce potential irritation.
If You Are Using Copaxone:
If you are injecting Copaxone, it is important that you NOT massage the injection site for at least 24 hours after the injection. Massaging the site right after injecting could cause destruction of the fat right under the skin, leading to lipoatrophy.
However, one of the most common side effects of Copaxone is hard, red lumps at injection sites, which typically appear 24 to 36 hours after the injection is given. Vigorously massaging these lumps (as long as you wait more than 24 hours after the injection was given) can help reduce the irritation and make them go away faster. Some people apply heat to the lumps, then massage them. I have even gotten a professional massage and asked the therapist to concentrate on any lumps she found.

