I had to read this article several times to make sure I understood it, and even now, I can't be quite sure.
It seems that researchers in Japan noticed that people with MS seemed to have a higher degree of hyperintensity from gadolinium in certain regions in the brain, the dentate nucleus and the globus pallidus. Gadolinium is the contrast agent used in MRIs to highlight active lesions, which are those lesions that indicate that a relapse is occurring.
The more MRIs with contrast that the people had undergone, the more gadolinium was seen on subsequent MRIs, leading researchers to believe that it didn't all get cleared from the body, as has previously been assumed.
The big question here is: Do people who have had more MRIs with contrast have more hyper intensity because they have had more gadolinium (because there has been a reason to give them more MRIs, as their MS is more active) or is the gadolinium itself somehow contributing to the higher number of active lesions?
If you have any thoughts or insight about this topic, please leave them in the comments section. I'd be very interested in reading them.
Read more about gadolinium:
- Gadolinium Warning for People with Kidney Disease
- Gadolinium-Enhanced Lesion
- Headaches After MRI Scans