Vitamin A Molecule Treats Early MS in Mice

In Japan, researchers have discovered that a molecule called "synthetic retinoid AM80" is successful in treating the early stages of multiple sclerosis in mice. Researchers use a "mouse model" of ms to test theories and develop early stages of treatments. In this model, certain immune cells (Th17) are the key factor in the multiple sclerosis-like condition created in the mice.

When researchers created Th17 MS-like mice and treated them with the molecule AM80 (which is a molecule related to Vitamin A), could stop/slow the early symptoms of MS in the mice. Could this mean a new route to treatment? Maybe, there is a lot of work to be done before it can be known.

Source: Klemann C, Raveney BJE, Klemann AK, Ozawa T, von Hörsten S, Shudo K, Oki S, Yamamura T. Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE. American Journal of Pathology, June, 2009; 174: 2234-2245

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